If a company has an advertisement in an electronic journal where the prescribing information is provided via a link and a pop-up appears to notify the reader that they are leaving the journal's site does this mean that the direct single click link requirement has not been met?

The necessary appearance of a pop-up alerting the user that they are about to access a different third party website will not affect compliance with the requirement to access the prescribing information via a direct single click link. See supplementary information to Clause 12.1